tl-setup only checks the "native" versions of dependencies. However we ship 32-bit libraries that require a 32-bit environment. tl-setup should be able to sort this out as well.
We may have to provide a question for this part though as some admins might want to have the system 64-bit only.
We could also trigger on the fact that we can find a 32-bit libc.
This mostly affects pcsctun, which requires glib. The other parts currently just need glibc, which must be installed if you able to run 32-bit applications.